| Athlete | 2025 | 2024 | Difference |
| Alyssa Wise - Waynesburg Central | 3:12.22 | 4:30.70 | - 1:18.48 |
| Madison Vinelli - Bradford Area | 2:55.15 | 3:53.63 | -58.48 |
| Brylee Kukowski - Mount Carmel Area | 3:15.81 | 4:09.93 | -54.12 |
| Melody Ann Marsh - Derry Area | 2:45.21 | 3:30.54 | -45.33 |
| Faith Krammes - Schuylkill Haven | 2:40.47 | 3:17.00 | -36.53 |
| Denise Ortiz - Calvary Christian Academy | 3:18.08 | 3:53.73 | -35.65 |
| Valerie Hauser - Laurel | 2:38.86 | 3:14.11 | -35.25 |
| Alicia Rodriguez - William Allen | 2:59.46 | 3:34.10 | -34.64 |
| Molly Drozd - North Allegheny | 3:07.94 | 3:41.89 | -33.95 |
| Jenna Pellick - Frazier | 2:38.66 | 3:10.81 | -32.15 |
| Soledad Lausch - Salisbury Township | 3:31.00 | 4:03.00 | -32 |
| Madison Dietz - Central Cambria | 3:36.16 | 4:06.68 | -30.52 |
| Lydia Fultz - Hamburg Area | 2:51.62 | 3:20.99 | -29.37 |
| Sophie Bennett - Northeast Bradford | 2:54.27 | 3:23.40 | -29.13 |
| Lauren Dever - McDowell | 2:34.95 | 3:02.54 | -27.59 |
| Claire Doherty - Pennsbury | 2:26.53 | 2:54.09 |